Organ transplantation has been accepted as a modality of treatment that improves the patient's suffering from endstage organ failure. There is a wide gap between organ supply and demand, resulting in a very long waiting time for organ transplantation, and an increasing number of deaths of the patients while on the waiting list. Islam has given permission for organ and tissue transplantation to save human lives or vital organs. Although brain death has been accepted as true death by many Muslim scholars and medical organizations, the consensus in the Muslim world is not unanimous. The public attitude toward donation is pivotal in all transplantation programs, and increasing the awareness of the leaders of religion is extremely vital.